Botox & Neurotoxins
Botulinum toxin injections temporarily relax specific facial muscles to soften dynamic wrinkles like frown lines, forehead lines, and crow's feet. Results are not permanent and typically last three to four months.
- Family
- Injectables
- Typical cost
- $10-$20 per unit, or roughly $200-$600 per treated area
- Updated
- July 13, 2026
What is Botox & Neurotoxins?
Botox is one brand of botulinum toxin type A, a purified protein that temporarily blocks nerve signals to targeted muscles. When a small amount is injected into a specific muscle, that muscle relaxes, which softens the overlying wrinkles caused by repeated movement. Other FDA-approved neurotoxin brands include Dysport, Xeomin, Jeuveau, and Daxxify. These products are commonly used for frown lines between the brows, horizontal forehead lines, and crow's feet, and some have additional approved medical uses such as chronic migraine and excessive sweating.
What to expect
A treatment visit is short, often 10 to 20 minutes, and involves several tiny injections with a fine needle. Most people describe brief stinging. There is little to no downtime, and you can usually return to normal activities the same day, though providers often advise avoiding heavy exercise, lying flat, and rubbing the area for a few hours. Results are not immediate; muscle-relaxing effects typically begin in 2 to 4 days and peak around 10 to 14 days. Effects generally last 3 to 4 months, after which movement gradually returns.
What the evidence says
Botulinum toxin for glabellar frown lines is supported by multiple randomized controlled trials and is FDA-approved for several cosmetic and medical indications. Systematic reviews and Cochrane analyses conclude it reliably reduces the appearance of dynamic wrinkles for a limited time, with a well-characterized short-term safety profile. Evidence is strongest for frown lines, forehead lines, and crow's feet; use in other facial areas is often off-label and supported by smaller studies and clinical experience rather than large trials. Long-term data on repeated use over many years is more limited.
Risks & who should avoid it
Common side effects include temporary bruising, redness, headache, and injection-site tenderness. Less commonly, spread to nearby muscles can cause a drooping eyelid or brow, uneven expression, or a temporary heavy feeling. People who are pregnant or breastfeeding, or who have neuromuscular disorders such as myasthenia gravis or ALS, or a known allergy to the product, should avoid it. Choose a licensed, experienced medical injector.
Questions
- How long does Botox last?
- Cosmetic results typically last about 3 to 4 months. As the effect wears off, muscle movement and wrinkles gradually return, and many people schedule maintenance treatments a few times a year.
- Does it hurt?
- Most people feel only brief stinging or pinching from the fine needle. Numbing cream or ice can be used, but it is generally considered a well-tolerated, quick procedure.
- When will I see results?
- Effects usually begin within 2 to 4 days and reach their peak around 10 to 14 days. It is best to wait two weeks before judging your final result or requesting a touch-up.
- Is Botox permanent?
- No. The effect is temporary because the treated nerve signals recover over time. If you stop treatments, your muscles and wrinkles return to their prior baseline rather than worsening.
- Are the different brands the same?
- Botox, Dysport, Xeomin, Jeuveau, and Daxxify are all botulinum toxin type A products with similar core effects, but they differ slightly in dosing, onset, and duration. Your provider can recommend one for your goals.
Available at
A curated list of clinics offering Botox & Neurotoxins is in the works. Clinicians — here's how to be included.
Related reading
A Microneedling Device Is Cleared for the Skin Around the Eyes
The FDA cleared SkinStylus for periorbital wrinkles across all skin types. Here is what the clearance means, and what it does not tell you yet.
A Small Trial Tests Botox Plus Collagen for Crow's-Feet
A randomized study asked whether adding a collagen filler to botulinum toxin improves periorbital wrinkles. The combination scored higher — in 40 people, over six months.
MedSpa Daily is an editorial publication, not a medical provider. Nothing here is medical advice — consult a licensed clinician about your own care.
Editorial only · MedSpa Daily does not sell or refer for treatments.